Similac® Human Milk Fortifier

Features

Infants fed Similac Human Milk Fortifier demonstrated excellent weight, length and head circumference gains¹

Specially formulated to mix easily with human milk

Low iron level provides flexibility to add iron as needed

A peer-reviewed clinical study showed that Similac Human Milk Fortifier, a low iron fortifier, preserved the antibacterial activity of breast milk against E. coli, Staph, GBS and E. sakazakii [now C. sakazakii].^2,*

Well tolerated

Small, convenient packaging designed for less spillage

Warning: Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by a physician.

Precautions

Nutritionally incomplete—to be used under the supervision of a doctor
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk. Once enteral feeding is well established, Similac Human Milk Fortifier can be added to human milk (see Preparation)
Human milk can be fortified with Similac Human Milk Fortifier until the low-birth-weight infant reaches a weight of approximately 3600 g (approximately 8 lb) or as directed by a doctor

^* Escherichia coli, Staphylococcus, Group B Streptococcus, and Enterobacter sakazakii (renamed Cronobacter sakazakii)

¹ Barrett-Reis B et al. Pediatrics 2000;106:581-588.

² Chan GM. J Perinatol 2003;23:620-623.

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Availability

List Number	Item
54598	Similac Human Milk Fortifier Powder Institutional / 0.9-g Packet / Case of 150

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Nutrition

Unflavored Powder

Similac Human Milk Fortifier Powder Institutional / 0.9-g Packet / Case of 150

Serving Size: 1 Packet (0.9 g)
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 3.5
Volume, mL:
Protein, g: 0.25
Protein, % Cal:
Protein, Source:
Fat, g: 0.09
Linoleic Acid, mg:
Fat, % Cal:
Fat, Source:
Carbohydrate, g: 0.45
Carbohydrate, % Cal:
Carbohydrate, Source:
Potential Renal Solute Load, mOsm: 2.8
Water, g:
Osmolality, mOsm/kg H2O:
Vitamins
Vitamin A, IU: 155
Vitamin D, IU: 30
Vitamin E, IU: 0.8
Vitamin K, mcg: 2.1
Thiamin (Vitamin B1), mcg: 58.3
Riboflavin (Vitamin B2), mcg: 104
Vitamin B6, mcg: 53
Vitamin B12, mcg: 0.16
Niacin, mcg: 893
Folic Acid (Folacin), mcg: 5.75
Pantothenic Acid, mcg: 375
Biotin, mcg: 6.5
Vitamin C (Ascorbic Acid), mg: 6.3
Choline, mg: 0.5
Inositol, mg: 1
Minerals
Calcium, mg: 29.25
Calcium, mEq: 1.46
Phosphorus, mg: 16.8
Phosphorus, mEq: 0.54
Magnesium, mg: 1.75
Iron, mg: 0.08^*
Zinc, mg: 0.25
Manganese, mcg: 1.8
Copper, mcg: 42.5
Iodine, mcg:
Selenium, mcg:
Sodium, mg: 3.75
Sodium, mEq: 0.16
Potassium, mg: 15.75
Potassium, mEq: 0.40
Chloride, mg: 9.5
Chloride, mEq: 0.27
^* Additional iron should be supplied from other sources.

Serving Size: 4 Packets (3.6 g)
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 14
Volume, mL:
Protein, g: 1.00
Protein, % Cal:
Protein, Source:
Fat, g: 0.36
Linoleic Acid, mg:
Fat, % Cal:
Fat, Source:
Carbohydrate, g: 1.80
Carbohydrate, % Cal:
Carbohydrate, Source:
Potential Renal Solute Load, mOsm: 11.2
Water, g:
Osmolality, mOsm/kg H2O:
Vitamins
Vitamin A, IU: 620
Vitamin D, IU: 120
Vitamin E, IU: 3.2
Vitamin K, mcg: 8.3
Thiamin (Vitamin B1), mcg: 233
Riboflavin (Vitamin B2), mcg: 417
Vitamin B6, mcg: 211
Vitamin B12, mcg: 0.64
Niacin, mcg: 3570
Folic Acid (Folacin), mcg: 23
Pantothenic Acid, mcg: 1500
Biotin, mcg: 26
Vitamin C (Ascorbic Acid), mg: 25
Choline, mg: 2.0
Inositol, mg: 4
Minerals
Calcium, mg: 117
Calcium, mEq: 5.84
Phosphorus, mg: 67
Phosphorus, mEq: 2.16
Magnesium, mg: 7.0
Iron, mg: 0.35^*
Zinc, mg: 1.00
Manganese, mcg: 7.2
Copper, mcg: 170
Iodine, mcg:
Selenium, mcg:
Sodium, mg: 15
Sodium, mEq: 0.65
Potassium, mg: 63
Potassium, mEq: 1.61
Chloride, mg: 38
Chloride, mEq: 1.07
^* Additional iron should be supplied from other sources.

Serving Size: 100 Cal - Preterm Human Milk^*,1,2
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 100
Volume, mL: 149
Protein, g: 2.10
Protein, % Cal: 8
Protein, Source: ^†
Fat, g: 5.80
Linoleic Acid, mg: 550
Fat, % Cal: 52
Fat, Source: ^†
Carbohydrate, g: 9.9
Carbohydrate, % Cal: 40
Carbohydrate, Source: ^‡
Potential Renal Solute Load, mOsm: 18.7
Water, g: 131
Osmolality, mOsm/kg H2O: 290
Vitamins
Vitamin A, IU: 581
Vitamin D, IU: 3
Vitamin E, IU: 1.6
Vitamin K, mcg: 0.3
Thiamin (Vitamin B1), mcg: 31
Riboflavin (Vitamin B2), mcg: 72
Vitamin B6, mcg: 22
Vitamin B12, mcg: 0.07
Niacin, mcg: 224
Folic Acid (Folacin), mcg: 5
Pantothenic Acid, mcg: 269
Biotin, mcg: 0.6
Vitamin C (Ascorbic Acid), mg: 16
Choline, mg: 14
Inositol, mg: 22.0
Minerals
Calcium, mg: 37
Calcium, mEq: 1.9
Phosphorus, mg: 19
Phosphorus, mEq:
Magnesium, mg: 4.6
Iron, mg: 0.18
Zinc, mg: 0.51
Manganese, mcg: 1
Copper, mcg: 96
Iodine, mcg: 16
Selenium, mcg: 2.2
Sodium, mg: 37
Sodium, mEq: 1.6
Potassium, mg: 85
Potassium, mEq: 2.2
Chloride, mg: 82
Chloride, mEq: 2.3
^* Composition of preterm human milk varies with maternal diet, stage of lactation, within feedings, diurnally, and among mothers.¹ Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium.² Values represent mature preterm milk (not colostrum or transitional milk).
^† Preterm Human Milk
^‡ Lactose
¹ Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56.
² American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy of Pediatrics. 1998;40;132-135, 217, 258, 655-658.

Serving Size: 100 Cal - Similac Human Milk Fortifier + Preterm Human Milk (1 pkt:50 mL)^*,1,2
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 100
Volume, mL: 137
Protein, g: 2.58
Protein, % Cal: 10
Protein, Source: ^†
Fat, g: 5.50
Linoleic Acid, mg: 498
Fat, % Cal: 49
Fat, Source: ^‡
Carbohydrate, g: 10.2
Carbohydrate, % Cal: 41
Carbohydrate, Source: ^§
Potential Renal Solute Load, mOsm: 24.5
Water, g: 119
Osmolality, mOsm/kg H2O: 343
Vitamins
Vitamin A, IU: 944
Vitamin D, IU: 84
Vitamin E, IU: 3.6
Vitamin K, mcg: 6
Thiamin (Vitamin B1), mcg: 185
Riboflavin (Vitamin B2), mcg: 347
Vitamin B6, mcg: 162
Vitamin B12, mcg: 0.50
Niacin, mcg: 2611
Folic Acid (Folacin), mcg: 20
Pantothenic Acid, mcg: 1256
Biotin, mcg: 18.1
Vitamin C (Ascorbic Acid), mg: 31
Choline, mg: 14
Inositol, mg: 22.5
Minerals
Calcium, mg: 112
Calcium, mEq: 5.6
Phosphorus, mg: 62
Phosphorus, mEq:
Magnesium, mg: 8.9
Iron, mg: 0.40^¶
Zinc, mg: 1.14
Manganese, mcg: 6
Copper, mcg: 202
Iodine, mcg: 14
Selenium, mcg: 2.3
Sodium, mg: 44
Sodium, mEq: 1.9
Potassium, mg: 119
Potassium, mEq: 3.0
Chloride, mg: 100
Chloride, mEq: 2.8
^* Composition of preterm human milk varies with maternal diet, stage of lactation, within feedings, diurnally, and among mothers.¹ Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium.² Values represent mature preterm milk (not colostrum or transitional milk).
^† Preterm Human Milk, Nonfat Milk, Whey Protein Concentrate
^‡ Preterm Human Milk, Medium-Chain Triglycerides
^§ Lactose, Corn Syrup Solids
^¶ Additional iron should be supplied from other sources.
¹ Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56.
² American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy of Pediatrics. 1998;40;132-135, 217, 258, 655-658.

Serving Size: 100 Cal - Similac Human Milk Fortifier + Preterm Human Milk (1 pkt:25 mL)^*,1,2
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 100
Volume, mL: 127
Protein, g: 2.97
Protein, % Cal: 12
Protein, Source: ^†
Fat, g: 5.24
Linoleic Acid, mg: 455
Fat, % Cal: 47
Fat, Source: ^‡
Carbohydrate, g: 10.4
Carbohydrate, % Cal: 42
Carbohydrate, Source: ^§
Potential Renal Solute Load, mOsm: 29.3
Water, g: 108
Osmolality, mOsm/kg H2O: 385
Vitamins
Vitamin A, IU: 1245
Vitamin D, IU: 150
Vitamin E, IU: 5.3
Vitamin K, mcg: 10
Thiamin (Vitamin B1), mcg: 313
Riboflavin (Vitamin B2), mcg: 574
Vitamin B6, mcg: 278
Vitamin B12, mcg: 0.85
Niacin, mcg: 4587
Folic Acid (Folacin), mcg: 32
Pantothenic Acid, mcg: 2072
Biotin, mcg: 32.6
Vitamin C (Ascorbic Acid), mg: 44
Choline, mg: 14
Inositol, mg: 22.9
Minerals
Calcium, mg: 175
Calcium, mEq: 8.7
Phosphorus, mg: 98
Phosphorus, mEq:
Magnesium, mg: 12.4
Iron, mg: 0.6^¶
Zinc, mg: 1.65
Manganese, mcg: 10
Copper, mcg: 289
Iodine, mcg: 13
Selenium, mcg: 2.4
Sodium, mg: 49
Sodium, mEq: 2.1
Potassium, mg: 148
Potassium, mEq: 3.8
Chloride, mg: 115
Chloride, mEq: 3.2
^* Composition of preterm human milk varies with maternal diet, stage of lactation, within feedings, diurnally, and among mothers.¹ Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium.² Values represent mature preterm milk (not colostrum or transitional milk).
^† Preterm Human Milk, Nonfat Milk, Whey Protein Concentrate
^‡ Preterm Human Milk, Medium-Chain Triglycerides
^§ Lactose, Corn Syrup Solids
^¶ Additional iron should be supplied from other sources.
¹ Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56.
² American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy of Pediatrics. 1998;40;132-135, 217, 258, 655-658.

Serving Size: 1000 mL - Preterm Human Milk^*,1,2
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 671
Volume, mL: 1000
Protein, g: 14.09
Protein, % Cal: 8
Protein, Source: ^†
Fat, g: 38.93
Linoleic Acid, mg: 3691
Fat, % Cal: 52
Fat, Source: ^†
Carbohydrate, g: 66.4
Carbohydrate, % Cal: 40
Carbohydrate, Source: ^‡
Potential Renal Solute Load, mOsm: 125.6
Water, g: 879
Osmolality, mOsm/kg H2O: 290
Vitamins
Vitamin A, IU: 3899
Vitamin D, IU: 20
Vitamin E, IU: 10.7
Vitamin K, mcg: 2.0
Thiamin (Vitamin B1), mcg: 208
Riboflavin (Vitamin B2), mcg: 483
Vitamin B6, mcg: 148
Vitamin B12, mcg: 0.47
Niacin, mcg: 1503
Folic Acid (Folacin), mcg: 33
Pantothenic Acid, mcg: 1805
Biotin, mcg: 4.0
Vitamin C (Ascorbic Acid), mg: 107
Choline, mg: 94
Inositol, mg: 147.7
Minerals
Calcium, mg: 248
Calcium, mEq: 12.4
Phosphorus, mg: 128
Phosphorus, mEq:
Magnesium, mg: 30.9
Iron, mg: 1.21
Zinc, mg: 3.42
Manganese, mcg: 6
Copper, mcg: 644
Iodine, mcg: 107
Selenium, mcg: 14.8
Sodium, mg: 248
Sodium, mEq: 10.8
Potassium, mg: 570
Potassium, mEq: 14.6
Chloride, mg: 550
Chloride, mEq: 15.6
^* Composition of preterm human milk varies with maternal diet, stage of lactation, within feedings, diurnally, and among mothers.¹ Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium.² Values represent mature preterm milk (not colostrum or transitional milk).
^† Preterm Human Milk
^‡ Lactose
¹ Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56.
² American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy of Pediatrics. 1998;40;132-135, 217, 258, 655-658.

Serving Size: 1000 mL - Similac Human Milk Fortifier + Preterm Human Milk (1 pkt:50 mL)^*,1,2
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 731
Volume, mL: 1000
Protein, g: 18.84
Protein, % Cal: 10
Protein, Source: ^†
Fat, g: 40.18
Linoleic Acid, mg: 3642
Fat, % Cal: 49
Fat, Source: ^‡
Carbohydrate, g: 74.4
Carbohydrate, % Cal: 41
Carbohydrate, Source: ^§
Potential Renal Solute Load, mOsm: 179.2
Water, g: 867
Osmolality, mOsm/kg H2O: 343
Vitamins
Vitamin A, IU: 6906
Vitamin D, IU: 612
Vitamin E, IU: 26.4
Vitamin K, mcg: 42.9
Thiamin (Vitamin B1), mcg: 1355
Riboflavin (Vitamin B2), mcg: 2534
Vitamin B6, mcg: 1187
Vitamin B12, mcg: 3.62
Niacin, mcg: 19,096
Folic Acid (Folacin), mcg: 146
Pantothenic Acid, mcg: 9181
Biotin, mcg: 132.2
Vitamin C (Ascorbic Acid), mg: 229
Choline, mg: 102
Inositol, mg: 164.7
Minerals
Calcium, mg: 822
Calcium, mEq: 41.0
Phosphorus, mg: 456
Phosphorus, mEq:
Magnesium, mg: 65.0
Iron, mg: 2.92^¶
Zinc, mg: 8.31
Manganese, mcg: 41
Copper, mcg: 1474
Iodine, mcg: 106
Selenium, mcg: 17.0
Sodium, mg: 319
Sodium, mEq: 13.9
Potassium, mg: 874
Potassium, mEq: 22.3
Chloride, mg: 730
Chloride, mEq: 20.6
^* Composition of preterm human milk varies with maternal diet, stage of lactation, within feedings, diurnally, and among mothers.¹ Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium.² Values represent mature preterm milk (not colostrum or transitional milk).
^† Preterm Human Milk, Nonfat Milk, Whey Protein Concentrate
^‡ Preterm Human Milk, Medium-Chain Triglycerides
^§ Lactose, Corn Syrup Solids
^¶ Additional iron should be supplied from other sources.
¹ Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56.
² American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy of Pediatrics. 1998;40;132-135, 217, 258, 655-658.

Serving Size: 1000 mL - Similac Human Milk Fortifier + Preterm Human Milk (1 pkt:25 mL)^*,1,2
Amount Per Serving	% DV	% RDI
Nutrient Data
Energy, Cal: 790
Volume, mL: 1000
Protein, g: 23.46
Protein, % Cal: 12
Protein, Source: ^†
Fat, g: 41.41
Linoleic Acid, mg: 3594
Fat, % Cal: 47
Fat, Source: ^‡
Carbohydrate, g: 82.2
Carbohydrate, % Cal: 42
Carbohydrate, Source: ^§
Potential Renal Solute Load, mOsm: 231.5
Water, g: 856
Osmolality, mOsm/kg H2O: 385
Vitamins
Vitamin A, IU: 9834
Vitamin D, IU: 1188
Vitamin E, IU: 41.6
Vitamin K, mcg: 82.8
Thiamin (Vitamin B1), mcg: 2471
Riboflavin (Vitamin B2), mcg: 4531
Vitamin B6, mcg: 2198
Vitamin B12, mcg: 6.69
Niacin, mcg: 36,225
Folic Acid (Folacin), mcg: 256
Pantothenic Acid, mcg: 16,364
Biotin, mcg: 257.1
Vitamin C (Ascorbic Acid), mg: 348
Choline, mg: 109
Inositol, mg: 181.3
Minerals
Calcium, mg: 1381
Calcium, mEq: 68.9
Phosphorus, mg: 777
Phosphorus, mEq:
Magnesium, mg: 98.2
Iron, mg: 4.58^¶
Zinc, mg: 13.07
Manganese, mcg: 76
Copper, mcg: 2283
Iodine, mcg: 105
Selenium, mcg: 19.2
Sodium, mg: 388
Sodium, mEq: 16.9
Potassium, mg: 1169
Potassium, mEq: 29.9
Chloride, mg: 906
Chloride, mEq: 25.5
^* Composition of preterm human milk varies with maternal diet, stage of lactation, within feedings, diurnally, and among mothers.¹ Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium.² Values represent mature preterm milk (not colostrum or transitional milk).
^† Preterm Human Milk, Nonfat Milk, Whey Protein Concentrate
^‡ Preterm Human Milk, Medium-Chain Triglycerides
^§ Lactose, Corn Syrup Solids
^¶ Additional iron should be supplied from other sources.
¹ Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56.
² American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy of Pediatrics. 1998;40;132-135, 217, 258, 655-658.

Ingredients

Unflavored Powder

Similac Human Milk Fortifier Powder Institutional / 0.9-g Packet / Case of 150

Nonfat Milk, Whey Protein Concentrate, Corn Syrup Solids, Medium-Chain Triglycerides, Calcium Phosphate, Potassium Citrate. Less than 2% of the Following: Soy Lecithin, Minerals (Magnesium Chloride, Sodium Citrate, Calcium Carbonate, Sodium Chloride, Potassium Phosphate, Zinc Sulfate, Ferrous Sulfate, Cupric Sulfate, Manganese Sulfate, Sodium Selenate), Vitamins (Vitamin A Palmitate, Vitamin D3, d-Alpha-Tocopheryl Acetate, Phylloquinone, Thiamin Chloride Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Cyanocobalamin, Niacinamide, Folic Acid, Calcium Pantothenate, Biotin, Ascorbic Acid, m-Inositol), and Potassium Hydroxide.
Contains milk and soy ingredients.

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Preparation

Powder

Use under supervision of a doctor. Add 1 packet of powder to desired quantity of human milk. The powder is to be mixed with measured amounts of human milk to provide an additional 2 or 4 Cal/fl oz, as shown below.

Additional Calories Desired (Cal/fl oz) Human Milk
(mL) Similac Human Milk Fortifier

2 50 1 packet (0.9 g)

4 25 1 packet (0.9 g)

CAUTION: Similac Human Milk Fortifier is nutritionally incomplete by itself and is designed to be added to human milk.
Powder
- Gently swirl container of human milk.
- Pour desired quantity of human milk into sterile container.
- Add 1 packet of Similac Human Milk Fortifier to:
- Gently swirl and feed.

Storage & Handling

Powder
- Cover prepared, unused fortified milk immediately.
- Store in refrigerator and use within 24 hours or according to hospital procedures for handling human milk.
- Swirl before using.
- Store unopened packets at room temperature; avoid extreme temperatures.

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Additional Calories Desired (Cal/fl oz)	Human Milk (mL)	Similac Human Milk Fortifier
2	50	1 packet (0.9 g)
4	25	1 packet (0.9 g)