Similac® Human Milk Fortifier

Similac® Human Milk Fortifier

  • Use under medical supervision.

  • Low iron level provides flexibility to add iron as needed.
  • A peer-reviewed clinical study showed that Similac Human Milk Fortifier, a low iron fortifier, preserved the antibacterial activity of breast milk against E. coli, Staph, GBS and E. sakazakii* [now C. sakazakii].
  • Small, convenient packaging designed for less spillage.
  • Halal.
  • Kosher.
Warning: Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by a physician. Please follow directions as specified. Improper dilution may be harmful.


  • Add only to human milk - do not add water.
  • Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk. Once enteral feeding is well established, Similac Human Milk Fortifier can be added to human milk (see Preparation).
  • Human milk can be fortified with Similac Human Milk Fortifier until the low-birth-weight infant reaches a weight of approximately 3600 g (approximately 8 lb) or as directed by a doctor.
* Escherichia coli, Staphylococcus, Group B Streptococcus, and Enterobacter sakazakii (renamed Cronobacter sakazakii)
1 Chan GM. J Perinatol 2003;23:620-623.
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List Number Item


Unflavored Powder

Serving Size: 4 Packets (3.6 g)

Amount Per Serving % DV % RDI
Nutrient Data
Protein, g: 1.0    
Fat, g: 0.36    
Carbohydrate, g: 1.8    
Calories: 14    
Potential Renal Solute Load, mOsm: 11.2    
Vitamin A, IU: 620    
Vitamin D, IU: 120    
Vitamin E, IU: 3.2    
Vitamin K, mcg: 8.3    
Thiamin (Vitamin B1), mcg: 233    
Riboflavin (Vitamin B2), mcg: 417    
Vitamin B6, mcg: 211    
Vitamin B12, mcg: 0.64    
Niacin, mg: 3.57    
Folic Acid (Folacin), mcg: 23    
Pantothenic Acid, mg: 1.5    
Biotin, mcg: 26    
Vitamin C (Ascorbic Acid), mg: 25    
Calcium, mg: 117    
Calcium, mEq: 5.84    
Phosphorus, mg: 67    
Phosphorus, mEq: 2.16    
Magnesium, mg: 7.0    
Iron, mg: 0.35    
Zinc, mg: 1.00    
Manganese, mcg: 7.2    
Copper, mcg: 170    
Sodium, mg: 15    
Sodium, mEq: 0.65    
Potassium, mg: 63    
Potassium, mEq: 1.61    
Chloride, mg: 38    
Chloride, mEq: 1.07    

Serving Size: 1 Packet (0.9 g)

Amount Per Serving % DV % RDI
Nutrient Data
Protein, g: 0.25    
Fat, g: 0.09    
Carbohydrate, g: 0.45    
Calories: 3.5    
Potential Renal Solute Load, mOsm: 2.8    
Vitamin A, IU: 155    
Vitamin D, IU: 30    
Vitamin E, IU: 0.8    
Vitamin K, mcg: 2.1    
Thiamin (Vitamin B1), mcg: 58.3    
Riboflavin (Vitamin B2), mcg: 104    
Vitamin B6, mcg: 53    
Vitamin B12, mcg: 0.16    
Niacin, mg: 0.89    
Folic Acid (Folacin), mcg: 5.75    
Pantothenic Acid, mg: 0.37    
Biotin, mcg: 6.5    
Vitamin C (Ascorbic Acid), mg: 6.3    
Calcium, mg: 29.25    
Calcium, mEq: 1.46    
Phosphorus, mg: 16.8    
Phosphorus, mEq: 0.54    
Magnesium, mg: 1.75    
Iron, mg: 0.08    
Zinc, mg: 0.25    
Manganese, mcg: 1.8    
Copper, mcg: 42.5    
Sodium, mg: 3.75    
Sodium, mEq: 0.16    
Potassium, mg: 15.75    
Potassium, mEq: 0.40    
Chloride, mg: 9.5    
Chloride, mEq: 0.27    

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Unflavored Powder

Nonfat Milk, Whey Protein Concentrate, Corn Syrup Solids, Medium-Chain Triglycerides, Calcium Phosphate, Potassium Citrate. Less than 2% of the Following: Soy Lecithin, Minerals (Magnesium Chloride, Sodium Citrate, Calcium Carbonate, Salt, Potassium Phosphate, Zinc Sulfate, Ferrous Sulfate, Cupric Sulfate, Manganese Sulfate, Sodium Selenate), Vitamins (Vitamin A Palmitate, Vitamin D3, d-Alpha-Tocopheryl Acetate, Phylloquinone, Thiamin Chloride Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Cyanocobalamin, Niacinamide, Folic Acid, Calcium Pantothenate, Biotin, Ascorbic Acid, m-Inositol), and Potassium Hydroxide.
Contains milk and soy ingredients.
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  • Powder
    This product is for premature and low-birth-weight infants. Proper hygiene, handling and storage are important when preparing fortified human milk. Failure to follow these directions could result in severe harm.

    Additional Calories Desired Human Milk
    Similac Human Milk Fortifier
    2 (Cal/fl oz) 50 mL 1 packet
    4 (Cal/fl oz) 25 mL 1 packet
    • Gently shake container of human milk. Pour desired quantity into clean feeding container.
    • To open packet, tear top off completely along perforation.
    • Add fortifier to human milk and gently shake.
      • Bottle Feeding: Discard one hour after feeding begins.
      • Tube Feeding: Limit hang time to a maximum of 4 hours.

Storage & Handling

  • Powder
    • Use immediately or store unused fortified human milk in the refrigerator; use within 24  hours or according to hospital procedures for handling human milk.
    • Gently shake before using.
    • Store unopened packets at room temperature; avoid extreme temperatures.

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