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Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

Similac<sup>®</sup> Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

SIMILAC HUMAN MILK FORTIFIER HYDROLYZED PROTEIN CONCENTRATED LIQUID is intended for premature and low-birth-weight infants including those infants less than 2000 g at hospital discharge<sup>1,2</sup> as a nutritional supplement to add to human milk. Use under medical supervision. Health care professionals should consult the Similac StrongMoms Premature Nutrition Discharge Program for information regarding product use post-discharge.

<sup>1</sup> Lapillonne AR, et al. J Pediatr. 2013; 162:S90-S100

<sup>2</sup> Koletzko B, Zhenghong L. Feeding after Discharge. In: Koletzko B, et al, Nutritional Care of Preterm Infants. 2nd edition. Karger; 2021: 325-339.

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Hospitals and institutions can order Abbott Nutrition products by calling 800-551-5838, Monday – Friday, 8:00 a.m. to 5:30 p.m. EST.

Established Abbott accounts can order online at e-Abbott.com.

Values listed below are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

List Number Item Market
63010 Similac Human Milk Fortifier Hydrolyzed Protein CL / 0.17 fl oz (5-mL) Packet / 6 x 24 ct Institutional

Hospitals and institutions can order Abbott Nutrition products by calling 800-551-5838, Monday – Friday, 8:00 a.m. to 5:30 p.m. EST.

5 mL (1 Packet)

Nutrition Data

Amount Per Serving %DV
Calories 7
Volume, mL 5
Protein, g 0.5
Fat, g 0.21
Carbohydrate, g 0.75
Water, g 3.3
Linoleic Acid, mg 18
Potential Renal Solute Load, mOsm 4.5
Osmolality, mOsm/kg H2O NA

Vitamins

Amount Per Serving %DV
Vitamin A, IU 197
Vitamin D, IU 35
Vitamin E, IU 1
Vitamin K, mcg 2.4
Thiamin (Vitamin B1), mcg 48
Riboflavin (Vitamin B2), mcg 74
Vitamin B6, mcg 50
Vitamin B12, mcg 0.13
Niacin, mcg 980
Folic Acid (Folacin), mcg 7
Pantothenic Acid, mcg 310
Biotin, mcg 5.8
Vitamin C (Ascorbic Acid), mg 7.7
Choline, mg 0.9
Inositol, mg 1.7

Minerals

Amount Per Serving %DV
Calcium, mg 30
Calcium, mEq 1.5
Phosphorus, mg 17
Magnesium, mg 2.1
Iron, mg 0.11
Zinc, mg 0.31
Manganese, mcg 2.2
Copper, mcg 15
Iodine, mcg 0.4
Selenium, mcg 0.2
Sodium, mg 7.5
Sodium, mEq 0.3
Potassium, mg 16.2
Potassium, mEq 0.4
Chloride, mg 13
Chloride, mEq 0.4

30 mL (1 packet mixed with 25 mL preterm human milk)

Nutrition Data

Amount Per Serving %DV
Calories 24
Volume, mL 30
Protein, g 0.85*
Fat, g 1.18
Carbohydrate, g 2.41*
Water, g 25.3
Linoleic Acid, mg 110†
Potential Renal Solute Load, mOsm 7.6
Osmolality, mOsm/kg H2O 450

Vitamins

Amount Per Serving %DV
Vitamin A, IU 295
Vitamin D, IU 36
Vitamin E, IU 1.3
Vitamin K, mcg 2.5
Thiamin (Vitamin B1), mcg 53
Riboflavin (Vitamin B2), mcg 86
Vitamin B6, mcg 53
Vitamin B12, mcg 0.14
Niacin, mcg 1010
Folic Acid, mcg 8
Pantothenic Acid, mcg 355
Biotin, mcg 5.9†
Vitamin C (Ascorbic Acid), mg 10.4
Choline, mg 3.3†
Inositol, mg 5.4†

Minerals

Amount Per Serving %DV
Calcium, mg 36
Calcium, mEq 1.8
Phosphorus, mg 20
Magnesium, mg 2.8
Iron, mg 0.14
Zinc, mg 0.39
Manganese, mcg 2.4†
Copper, mcg 31
Iodine, mcg 3.1†
Selenium, mcg 0.5†
Sodium, mg 13.7
Sodium, mEq 0.6
Potassium, mg 30.4
Potassium, mEq 0.8
Chloride, mg 27
Chloride, mEq 0.8

<sup>*</sup>When mixed with 25 mL Term Human Milk. Protein is 0.76 g and Carbohydrate is 2.55 g/30 mL. Preterm human milk values from Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, OH: Abbott, Abbott Laboratories, January 1998.

<sup>&dagger;</sup>Values based on term human milk from American Academy of Pediatrics.. "Pediatric Nutrition Handbook", ed 4. Elk Grove Village: American Academy of Pediatrics, 1998, pp 217, 258, 655-658.

100 mL*

Nutrition Data

Amount Per Serving %DV
Calories 79
Volume, mL 100
Protein, g 2.84
Fat, g 3.94
Carbohydrate, g 8.04
Water, g 84
Linoleic Acid, mg 368
Potential Renal Solute Load, mOsm 25.5
Osmolality, mOsm/kg H2O 450

Vitamins

Amount Per Serving %DV
Vitamin A, IU 982
Vitamin D, IU 118
Vitamin E, IU 4.2
Vitamin K, mcg 8.2
Thiamin (Vitamin B1), mcg 177
Riboflavin (Vitamin B2), mcg 287
Vitamin B6, mcg 179
Vitamin B12, mcg 0.47
Niacin, mcg 3392
Folic Acid (Folacin), mcg 26.1
Pantothenic Acid, mcg 1184
Biotin, mcg 19.7
Vitamin C (Ascorbic Acid), mg 34.6
Choline, mg 10.8
Inositol, mg 18

Minerals

Amount Per Serving %DV
Calcium, mg 121
Calcium, mEq 6
Phosphorus, mg 67
Magnesium, mg 9.6
Iron, mg 0.47
Zinc, mg 1.32
Manganese, mcg 7.8
Copper, mcg 104
Iodine, mcg 10
Selenium, mcg 2
Sodium, mg 46
Sodium, mEq 1.9
Potassium, mg 102
Potassium, mEq 2.5
Chloride, mg 89
Chloride, mEq 2.6

<sup>*</sup>Preterm human milk values from "Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital", Columbus, OH, Abbott Nutrition, Abbott Laboratories, Jan 1998.

100 Cal (~4 packets mixed with 100 mL preterm human milk)

Nutrition Data

Amount Per Serving %DV
Calories 100*
Volume, mL 126
Protein, g 3.58
Fat, g 4.98
Carbohydrate, g 10.14
Water, g 106
Linoleic Acid, mg 464
Potential Renal Solute Load, mOsm 32.1
Osmolality, mOsm/kg H2O 450

Vitamins

Amount Per Serving %DV
Vitamin A, IU 1238
Vitamin D, IU 149
Vitamin E, IU 5.3
Vitamin K, mcg 10.3
Thiamin (Vitamin B1), mcg 224
Riboflavin (Vitamin B2), mcg 362
Vitamin B6, mcg 226
Vitamin B12, mcg 0.6
Niacin, mcg 4279
Folic Acid, mcg 32.9
Pantothenic Acid, mcg 1494
Biotin, mcg 24.8
Vitamin C (Ascorbic Acid), mg 43.7
Choline, mg 13.7
Inositol, mg 22.7

Minerals

Amount Per Serving %DV
Calcium, mg 152
Calcium, mEq 7.6
Phosphorus, mg 85
Magnesium, mg 12.1
Iron, mg 0.59
Zinc, mg 1.66
Manganese, mcg 9.9
Copper, mcg 131
Iodine, mcg 13
Selenium, mcg 2
Sodium, mg 58
Sodium, mEq 2.4
Potassium, mg 128
Potassium, mEq 3.2
Chloride, mg 113
Chloride, mEq 3.3

<sup>*</sup>Per 100 Calories, as fed, approximately 4 packets in 100 mL preterm human milk. Preterm human milk values from "Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100)." Columbus, OH: Abbott Nutrition, Abbott Laboratories, Jan 1998.

<sup>&dagger;</sup>Values based on term human milk from American Academy of Pediatrics.. "Pediatric Nutrition Handbook", ed 4. Elk Grove Village: American Academy of Pediatrics, 1998, pp 217, 258, 655-658.

Features
  • <!--StartFragment --><span class="cf0">A clinical study demonstrated infants in the strict protocol followers group achieved greater weight and length by the end of the study. Infants fed SHMF HP CL weighed half a pound more at the end of the study</span><!--EndFragment -->.<sup>3,*</sup>
  • Extensively hydrolyzed protein for easy digestion and absorption.
  • Non-acidified.
  • DHA for brain and eye development.
  • Lutein to support eye development.
  • When added to human milk, meets expert recommendations for protein<sup>&dagger;</sup> and other nutrients for the preterm infant.<sup>4,5</sup>
  • Well tolerated.
  • Small, convenient packet is designed for easy mixing.
  • Commercially sterile and meets the Academy of Nutrition and Dietetics and Centers for Disease Control and Prevention (CDC) recommendation to use liquid for NICU feedings.<sup>6,7</sup>
  • Low iron level provides flexibility to add iron as needed.
  • Gluten-free.

Precautions
  • Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
  • This product is nutritionally incomplete by itself. Add only to human milk—do not add water.
  • Additional iron may be necessary.
  • Not intended for feeding low-birth-weight infants <br /> <ul> <li>after achieving a body weight of 3600 g (approximately 8 lbs)</li> <li>after reaching 40 weeks postmenstrual age</li> <li>after 12 weeks post-discharge</li> <li>or as directed by a physician.</li> </ul>
  • Use once enteral (oral or by tube) feeding is well-established.

<sup>*</sup> Compared to control HMF.

<sup>&dagger;</sup> One packet mixed with 25 mL of human milk.

<sup>3</sup> Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

<sup>4</sup> Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

<sup>5</sup> Embleton ND, et al. JPGN 2022;76:248–268.

<sup>6</sup> Centers for Disease Control and Prevention. Enterobacter sakazakii infections associated with the use of powdered infant formula—Tennessee, 2001. Available at <A href="http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5114a1.htm">http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5114a1.htm</A>. Published April 11, 2002. Accessed May 31, 2024.

<sup>7</sup> Pediatric Nutrition Practice Group. Steele C, Collins E (eds). Infant and Pediatric Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities, 3rd Ed. Academy of Nutrition and Dietetics. 2019:12.

Unflavored Concentrated Liquid

Water, Corn Maltodextrin, Casein Hydrolysate. Less than 2% of: M. Alpina Oil*, Schizochytrium Sp. Oil†, Lutein, Beta-Carotene, Calcium Phosphate, Magnesium Chloride, Potassium Citrate, Sodium Citrate, Salt, Potassium Chloride, Potassium Phosphate, Zinc Sulfate, Ferrous Sulfate, Copper Sulfate, Manganese Sulfate, Sodium Selenite, Medium Chain Triglycerides, Soy Oil, Coconut Oil, Modified Corn Starch, Vitamin A Palmitate, Vitamin D3, dl-Alpha-Tocopheryl Acetate, Phylloquinone, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Vitamin B12, Niacinamide, Folic Acid, Calcium Pantothenate, Biotin, Ascorbic Acid, Inositol, Choline Chloride, Monoglycerides, L-Tyrosine, L-Leucine, L-Tryptophan, L-Carnitine, Gellan Gum, and Potassium Hydroxide.
* Source of ARA.
† Source of DHA.

Contains milk ingredients.

Preparation

INSTRUCTIONS FOR USE:

This product is for premature and low-birth-weight infants including those infants less than 2000 g at hospital discharge. For post-discharge use, follow the doctor's instructions as specified for your baby. Proper hygiene, handling and storage are important when preparing fortified human milk. Improper mixing may not meet your baby's nutritional needs.

Use

Additional Calories DesiredHuman MilkSimilac Human Milk FortifierApproximate Yield
2 Calories / fl oz50 mL1 packet55 mL
4 Calories / fl oz25 mL1 packet30 mL

Follow instructions for safe handling of human milk. Consult with doctor on the need to boil (sterilize) bottles, nipples, and rings.

  1. Pour desired quantity of human milk into sterile feeding container.
  2. Product separation is normal. Massage contents until uniform.
  3. To open packet, tear top off completely along perforation.
  4. Add contents to human milk; cap and shake until mixed well. Once bottle feeding begins, use within one hour or discard.

Storing Fortified Human Milk
  • When more than one feeding is prepared, date and refrigerate unused portion; discard after 24 hours.
  • After refrigeration, remix gently if needed. Feed promptly.

STORAGE AND HANDLING:
  • Product is light sensitive.
  • Keep unopened packets in closed carton at room temperature; avoid extreme temperatures.


Similac<sup>®</sup> Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

SIMILAC HUMAN MILK FORTIFIER HYDROLYZED PROTEIN CONCENTRATED LIQUID is intended for premature and low-birth-weight infants including those infants less than 2000 g at hospital discharge<sup>1,2</sup> as a nutritional supplement to add to human milk. Use under medical supervision. Health care professionals should consult the Similac StrongMoms Premature Nutrition Discharge Program for information regarding product use post-discharge.

<sup>1</sup> Lapillonne AR, et al. J Pediatr. 2013; 162:S90-S100

<sup>2</sup> Koletzko B, Zhenghong L. Feeding after Discharge. In: Koletzko B, et al, Nutritional Care of Preterm Infants. 2nd edition. Karger; 2021: 325-339.

Similac<sup>®</sup> Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

Features

  • <!--StartFragment --><span class="cf0">A clinical study demonstrated infants in the strict protocol followers group achieved greater weight and length by the end of the study. Infants fed SHMF HP CL weighed half a pound more at the end of the study</span><!--EndFragment -->.<sup>3,*</sup>
  • Extensively hydrolyzed protein for easy digestion and absorption.
  • Non-acidified.
  • DHA for brain and eye development.
  • Lutein to support eye development.
  • When added to human milk, meets expert recommendations for protein<sup>&dagger;</sup> and other nutrients for the preterm infant.<sup>4,5</sup>
  • Well tolerated.
  • Small, convenient packet is designed for easy mixing.
  • Commercially sterile and meets the Academy of Nutrition and Dietetics and Centers for Disease Control and Prevention (CDC) recommendation to use liquid for NICU feedings.<sup>6,7</sup>
  • Low iron level provides flexibility to add iron as needed.
  • Gluten-free.

<sup>*</sup> Compared to control HMF.

<sup>&dagger;</sup> One packet mixed with 25 mL of human milk.

<sup>3</sup> Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

<sup>4</sup> Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

<sup>5</sup> Embleton ND, et al. JPGN 2022;76:248–268.

<sup>6</sup> Centers for Disease Control and Prevention. Enterobacter sakazakii infections associated with the use of powdered infant formula—Tennessee, 2001. Available at <A href="http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5114a1.htm">http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5114a1.htm</A>. Published April 11, 2002. Accessed May 31, 2024.

<sup>7</sup> Pediatric Nutrition Practice Group. Steele C, Collins E (eds). Infant and Pediatric Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities, 3rd Ed. Academy of Nutrition and Dietetics. 2019:12.

Safety Precautions

  • Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
  • This product is nutritionally incomplete by itself. Add only to human milk—do not add water.
  • Additional iron may be necessary.
  • Not intended for feeding low-birth-weight infants
    • after achieving a body weight of 3600 g (approximately 8 lbs)
    • after reaching 40 weeks postmenstrual age
    • after 12 weeks post-discharge
    • or as directed by a physician.
  • Use once enteral (oral or by tube) feeding is well-established.

Availability

List Number Item
63010 Similac Human Milk Fortifier Hydrolyzed Protein CL / 0.17 fl oz (5-mL) Packet / 6 x 24 ct

Ingredients

Unflavored Concentrated Liquid

Water, Corn Maltodextrin, Casein Hydrolysate. Less than 2% of: M. Alpina Oil*, Schizochytrium Sp. Oil†, Lutein, Beta-Carotene, Calcium Phosphate, Magnesium Chloride, Potassium Citrate, Sodium Citrate, Salt, Potassium Chloride, Potassium Phosphate, Zinc Sulfate, Ferrous Sulfate, Copper Sulfate, Manganese Sulfate, Sodium Selenite, Medium Chain Triglycerides, Soy Oil, Coconut Oil, Modified Corn Starch, Vitamin A Palmitate, Vitamin D3, dl-Alpha-Tocopheryl Acetate, Phylloquinone, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Vitamin B12, Niacinamide, Folic Acid, Calcium Pantothenate, Biotin, Ascorbic Acid, Inositol, Choline Chloride, Monoglycerides, L-Tyrosine, L-Leucine, L-Tryptophan, L-Carnitine, Gellan Gum, and Potassium Hydroxide.
* Source of ARA.
† Source of DHA.

Contains milk ingredients.

Nutrition Information

5 mL (1 Packet)
Value%DV
30 mL (1 packet mixed with 25 mL preterm human milk)
Value%DV
100 mL*
Value%DV
100 Cal (~4 packets mixed with 100 mL preterm human milk)
Value%DV

<sup>*</sup>When mixed with 25 mL Term Human Milk. Protein is 0.76 g and Carbohydrate is 2.55 g/30 mL. Preterm human milk values from Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, OH: Abbott, Abbott Laboratories, January 1998.

<sup>&dagger;</sup>Values based on term human milk from American Academy of Pediatrics.. "Pediatric Nutrition Handbook", ed 4. Elk Grove Village: American Academy of Pediatrics, 1998, pp 217, 258, 655-658.

<sup>*</sup>Preterm human milk values from "Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital", Columbus, OH, Abbott Nutrition, Abbott Laboratories, Jan 1998.

<sup>*</sup>Per 100 Calories, as fed, approximately 4 packets in 100 mL preterm human milk. Preterm human milk values from "Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100)." Columbus, OH: Abbott Nutrition, Abbott Laboratories, Jan 1998.

<sup>&dagger;</sup>Values based on term human milk from American Academy of Pediatrics.. "Pediatric Nutrition Handbook", ed 4. Elk Grove Village: American Academy of Pediatrics, 1998, pp 217, 258, 655-658.

Preparation

INSTRUCTIONS FOR USE:

This product is for premature and low-birth-weight infants including those infants less than 2000 g at hospital discharge. For post-discharge use, follow the doctor's instructions as specified for your baby. Proper hygiene, handling and storage are important when preparing fortified human milk. Improper mixing may not meet your baby's nutritional needs.

Use

Additional Calories DesiredHuman MilkSimilac Human Milk FortifierApproximate Yield
2 Calories / fl oz50 mL1 packet55 mL
4 Calories / fl oz25 mL1 packet30 mL

Follow instructions for safe handling of human milk. Consult with doctor on the need to boil (sterilize) bottles, nipples, and rings.

  1. Pour desired quantity of human milk into sterile feeding container.
  2. Product separation is normal. Massage contents until uniform.
  3. To open packet, tear top off completely along perforation.
  4. Add contents to human milk; cap and shake until mixed well. Once bottle feeding begins, use within one hour or discard.

Storing Fortified Human Milk
  • When more than one feeding is prepared, date and refrigerate unused portion; discard after 24 hours.
  • After refrigeration, remix gently if needed. Feed promptly.

STORAGE AND HANDLING:
  • Product is light sensitive.
  • Keep unopened packets in closed carton at room temperature; avoid extreme temperatures.


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